Metabolic Dynamics During Physical Activity

Charité University Medicine Berlin

Status: Completed

Conditions: Healthy Men and Women

Treatments: Other: running on a treadmill under normoxia or hypoxia

Study type: Interventional

Funder types: Other

Identifiers

NCT03485716

Hypoxitrain 2

Details and patient eligibility

About

The aim of this study is to systematically Analyse the metabolome in capillary blood of healthy men and women at rest and during defined standardized physical activity under normobaric normoxia or hypoxia with a specific focus on metabolites and metabolic pattern related to energy metabolism. The metabolome analyses in capillary blood could give us also or more detailed insight into erythrocyte metabolic physiology because it is known for a longer time that the primary metabolism of the erythrocyte reflects its Oxygen Saturation via the glycolytic metabolites / intermediates pattern.

Enrollment: 34 patients

Sex: All

Ages: 18 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy volunteers
• written informed consent

Exclusion criteria

• known cardio-vascular, lung, metabolic, endocrine, hematologic, kidney or neurologic diseases
• pregnancy, lactating period
• unability to understand study content and aims and to give written informed consent

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

---

34 participants in 2 patient groups

running under hypoxia - first

Experimental group

Description:

running under hypoxia (first day) and normoxia (second day)

Treatment:

Other: running on a treadmill under normoxia or hypoxia

running under normoxia - first

Active Comparator group

Description:

running under normoxia (first day) and hypoxia (second day)

Treatment:

Other: running on a treadmill under normoxia or hypoxia