Metabolic Effects of Acute Cortisol Withdrawal in Adrenal Failure

University of Aarhus

Status: Completed

Conditions: Addison Syndrome

Treatments: Drug: hydrocortisone substitution therapy versus withdrawal

Study type: Interventional

Funder types: Other

Identifiers

NCT00442390

1998/4375

Details and patient eligibility

About

Effects of adrenal steroids is generelly drawn from studies of hypercortisolism. The effects of physiological cortisol substitution and withdrawal is studied and related to the clinical syndrome of adrenal insufficiency.

Sex: Female

Ages: 18 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Female adrenal failure
• Age 18-50
• Written informed content

Exclusion criteria

• Diabetes mellitus
• Cancer
• Thromboembolic events
• Pregnancy and lactation
• Heart disease

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)