Metabolic Effects of Fructose Intake

Baylor College of Medicine

Status: Completed

Conditions: Healthy

Treatments: Dietary Supplement: Glucose Ingestion; Dietary Supplement: Fructose Ingestion

Study type: Interventional

Funder types: Other

Identifiers

NCT06671756

H55353

Details and patient eligibility

About

The goal of this clinical trial is to learn how fructose ingestion affects metabolic factors in healthy adults aged 18-64, with a BMI between 19 and 30 kg/m², of any sex or gender. Specifically, the study aims to examine the impact of fructose compared to glucose on circulating metabolic factors including the soluble leptin receptor.

The main questions it aims to answer are:

How does fructose ingestion influence levels of circulating metabolic markers, including the soluble leptin receptor? Does fructose consumption have different metabolic effects compared to glucose?

Participants will:

Complete a screening phone call to review their health history and eligibility.

Attend two in-person visits at least two weeks apart, where they will:

Fast for 8 hours beforehand. Consume a beverage containing either 75g of fructose or glucose. Have blood drawn at regular intervals for up to 5 hours after consumption to measure circulating levels of metabolic markers.

Enrollment: 8 patients

Sex: All

Ages: 18 to 64 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age: Participants must be between 18 and 64 years old.
• BMI: Participants must have a Body Mass Index (BMI) between 19 and 30 kg/m² (healthy weight to slightly overweight).
• Health Status: Participants must be healthy volunteers with no significant medical conditions.
• Sex/Gender: Both males and females are eligible to participate.

Exclusion criteria

• Known significant medical illness, any medications except oral contraceptives, history of fructose intolerance, pregnancy. We will not enroll BCM Medical students or individuals who work directly for any of the study investigators.

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

---

8 participants in 2 patient groups

Fructose First, Glucose Second (10 participants)

Experimental group

Description:

Participants will first consume 75g of fructose in 225ml of water. Blood samples will be taken at specific intervals to measure metabolic responses. After 2 weeks, they will consume 75g of glucose in 225ml of water, with blood samples taken at the same intervals.

Treatment:

Dietary Supplement: Fructose Ingestion

Dietary Supplement: Glucose Ingestion

Glucose First, Fructose Second (10 participants)

Experimental group

Description:

Participants will first consume 75g of glucose in 225ml of water, followed by the same blood sampling schedule. After 2 weeks, they will switch to 75g of fructose, with blood samples taken at the same intervals.

Treatment:

Dietary Supplement: Fructose Ingestion

Dietary Supplement: Glucose Ingestion