Metabolic Effects of Medium-Chain Fatty Acids in Patients with Medium-Chain Acyl-CoA Dehydrogenase Deficiency and Healthy Individuals (MEMCADD)

University of Copenhagen

Status: Enrolling

Conditions: Medium-chain Acyl-CoA Dehydrogenase Deficiency

Treatments: Other: Medium-Chain Fatty Acid (MCFA); Other: Long-Chain Fatty Acid (LCFA)

Study type: Interventional

Funder types: Other

Identifiers

NCT06623032

NNF22OC0074110 (Other Grant/Funding Number)

H-24044278

Details and patient eligibility

About

The aim of this project is to investigate the physiological effects of intake of long-chain fatty acids (LCFA) and medium-chain fatty acids (MCFA) in patients with Medium-Chain Acyl-CoA Dehydrogenase Deficiency (MCADD) and healthy individuals

Full description

Male and female MCADD patients and healthy individuals will be included in this study which is a randomized intervention study in a cross over design consisting of two separate test days.

The study involves two test days of four hours each, during which the participants ingests either medium-chain fatty acids (MCFA) or long-chain fatty acids (LCFA) in the form of triacylglycerol oils. The order of fatty acid oils ingested is determined by randomization.

Enrollment: 30 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria MCADD patients:

• Male or female
• Age between 18-80 years old
• Diagnosed Medium-chain acyl-CoA dehydrogenase deficiency (MCADD

Inclusion Criteria Healthy Participants:

• Male or female
• Age between 18-80 years old

Exclusion Criteria both MCADD patients and healthy participants:

• Diabetes
• Kidney- or liver disease
• Use of beta blockers or diuretics
• Pregnant, lactating or planning to become pregnant within the study period
• Regular intake of substantial amounts of coconut oil, palm kernel oil or any other source abundant in MCFA
• Ongoing cancer treatment
• Metabolic or absorptive disorders, gastric bypass operation, or use of medication affecting metabolism or food absorption
• Inability, physically or mentally, to comply with the procedure required by the study protocol as evaluated by the primary investigator, study manager or clinical responsible

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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30 participants in 2 patient groups

Healthy Participants

Experimental group

Treatment:

Other: Long-Chain Fatty Acid (LCFA)

Other: Medium-Chain Fatty Acid (MCFA)

MCADD Patients

Experimental group

Treatment:

Other: Long-Chain Fatty Acid (LCFA)

Other: Medium-Chain Fatty Acid (MCFA)