Metabolic Phenotyping in Anorexia Nervosa

Charité University Medicine Berlin

Status: Withdrawn

Conditions: Anorexia Nervosa

Study type: Observational

Funder types: Other

Identifiers

NCT02087280

HA 7034/2-1 (Other Identifier)

VHaas

Details and patient eligibility

About

After discharge from inpatient treatment, 30-50% of patients with Anorexia Nervosa require re-hospitalization within 4-12 months. So far, high relapse rates are mostly considered as lack of the patient's compliance and motivation to recover. However in studies, psychological relapse predictors explain only a minor part of the variance in relapse risk. Metabolic phenotyping has clinical value to predict weight course in obese patients and we assume that it could also be clinically relevant in patients with AN. We hypothesize that in patients with a dissipative but not with the thrifty phenotype, positive energy balance during refeeding causes an over proportional rise in energy expenditure, counteracts continuous weight gain during inpatient treatment, and increases relapse risk within one year after discharge. Thus we believe that metabolic phenotype as a biological parameter has prognostic value for the disease course in AN.

Sex: Female

Ages: 12 to 18 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Diagnosis of Anorexia Nervosa
• Between 12 and 18 years of age
• Written and informed consent of patient and parents
• Mental ability to understand the concept of the study
• Inpatient admission to Charité University Clinic with body weight below the 10th BMI-Percentile

Exclusion criteria

• Any further disease other than AN with significant influence on body composition and energy metabolism or its assessment

Trial design

0 participants in 2 patient groups

Anorexia Nervosa

Healthy controls