Metabolic Response to 3-day Fast Versus Carbohydrate-free Diet in Type 2 Diabetes (CHO-free diet)

Minneapolis Veterans Affairs Health Care System (VAHCS)

Status: Completed

Conditions: Type 2 Diabetes

Treatments: Other: 3 day fast; Other: 3 day CHO-free diet

Study type: Interventional

Funder types: Other U.S. Federal agency

Identifiers

NCT01469104

4177

Details and patient eligibility

About

The investigators hypothesis is that a carbohydrate-free diet, ingested for 3 days, results in a change in blood glucose that is similar to the change observed after 3 days of fasting.

Full description

In addition to plasma glucose concentrations, other hormones and metabolites known to be affected by fasting will be measured. These include insulin and glucagon, which are hormones that have an important role in regulating fuel use in the body.

Enrollment: 7 patients

Sex: All

Ages: 45 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Type 2 diabetes
• C-peptide > 1.5 ng/ml

Exclusion criteria

• Body mass index > 40
• hematological abnormalities
• liver disease
• kidney disease
• congestive heart failure
• life threatening malignancies

Trial design

7 participants in 2 patient groups, including a placebo group

3 day fast

Placebo Comparator group

Description:

After receiving a standard diet on day 1, subject will fast on days 2, 3, and 4. Water and calorie-fee beverages will be allowed during this 72 hour period.

Treatment:

Other: 3 day fast

CHO-free diet

Active Comparator group

Description:

After receiving a standard diet on day 1, a carbohydrate-free diet will be provided on days 2, 3, and 4.

Treatment:

Other: 3 day CHO-free diet