Metabolic Response to Fat and Glucose

Universität des Saarlandes

Status: Completed

Conditions: Healthy; Insulin Resistance; Obesity

Treatments: Other: Glucose tolerance test; Other: Fat tolerance test

Study type: Interventional

Funder types: Other

Identifiers

NCT02603237

Postprandial metabolomics

Details and patient eligibility

About

The study will compare plasma and urine post-prandial metabolomics after fat and glucose oral load according to lifestyle factors.

Full description

The metabolic response in plasma and urine, pre- and post-load tests in people with specific dietary lifestyles will be tested. This project will focus on fat and glucose induced changes of targeted metabolic pathways that have been related to diabetes and obesity risk.

Enrollment: 60 patients

Sex: All

Ages: 40 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy volunteers
• On a stable dietary habits

Exclusion criteria

• Pregnancy
• Malabsorption disorders
• Present or former cancer
• Any oral medication that affect glucose or fat absorptions
• Cholesterol lowering drugs (i.e. Statins)
• other drugs: fibrates, MTX, or vitamin supplements
• Diabetes (type 1 and type 2)
• Alcoholism
• Weight losing diet during the last 4 months
• Liver diseases
• Renal dysfunction
• Gastric resection.

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

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60 participants in 2 patient groups

Glucose tolerance test

Other group

Description:

All participants will receive an oral standardized glucose tolerance test

Treatment:

Other: Glucose tolerance test

Fat tolerance test

Other group

Description:

The same participants will receive an oral standardized fat load test

Treatment:

Other: Fat tolerance test