Metabolic Risk Factors and Myocardial Oxygenation Reserve ((META-MORE))

McGill University

Status

Enrolling

Conditions

Metabolic Syndrome

Treatments

Diagnostic Test: Cardiac MRI

Study type

Observational

Funder types

Other

Identifiers

NCT05574153

2021-7267

Details and patient eligibility

About

The purpose of this study is to use MRI images using the OS-CMR technique to view the differences in the hearts of healthy volunteers and participants with a condition called Metabolic Syndrome. The objectives of this project are to compare these two groups and to view how health risks, blood test results, and the time since a Metabolic diagnosis can affect heart health.

Full description

Myocardial oxygenation changes during vasoactive breathing maneuvers, observed with oxygenation-sensitive cardiac MRI, will be identified and compared between individuals considered healthy and those fitting the criteria of the Metabolic Syndrome.

Enrollment

75 estimated patients

Sex

All

Ages

18 to 80 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Patient Participants:

Age 18-80
Informed Consent
Diagnosis of MetS (through at least 3 MetS characteristics (abdominal obesity, high triglyceride level, low HDL cholesterol, high systolic blood pressure, and high fasting glucose levels)

Healthy Volunteers:

Age 18-80
No known current or pre-existing significant medical problems that would affect the cardiovascular or respiratory system
No Smoking

Exclusion criteria

General MRI contraindications*
Pacemakers, defibrillating wires, implanted defibrillators, intracranial aneurysm clips, metallic foreign bodies in the eyes, knowledge or suspicion of pregnancy.
Consumption of caffeine (coffee, tea, cocoa, chocolate, "energy drink") during the 12 hours prior to the exam