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Metabolic Study of Concentric and Eccentric Muscle Training

V

Vorarlberg Institute for Vascular Investigation and Treatment

Status

Completed

Conditions

Lipid Metabolism
Inflammation
Insulin Resistance

Treatments

Behavioral: physical training

Study type

Interventional

Funder types

Other

Identifiers

NCT00386854
K01-2003-1

Details and patient eligibility

About

The purpose of this study is to evaluate the metabolic and anti-inflammatory effects of eccentric endurance exercise and to compare them with those of concentric exercise in healthy sedentary individuals.

Full description

Physical exercise decreases the risk of obesity, diabetes mellitus, and cardiovascular disease. Skeletal muscle can be exercised by two ways: Concentric contraction is defined as active shortening of muscles, e.g. by stepping upwards, whereas eccentric muscle contraction is defined as active resistance to stretching, e.g. by stepping downwards. Although the effects of exercise (i.e. the combination of concentric and eccentric muscle contraction) on metabolic parameters have been extensively investigated, there are no data on the specific metabolic effects of concentric versus those of eccentric muscle work in humans.

Comparison(s): Metabolic and anti-inflammatory effects of eccentric endurance exercise (i.e. stepping upwards), compared to metabolic and anti-inflammatory effects of concentric exercise (i.e. stepping downwards).

Sex

All

Ages

30+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • healthy men and women
  • age over 30 years

Exclusion criteria

  • previous systematic endurance training (≥3 times per week ≥30 min)
  • body mass index >30 kg/m2
  • heavy smoking (>20 cigarettes per day)
  • regular alcohol consumption >60g per day
  • established musculoskeletal disease
  • history of cardiovascular disease
  • diabetes mellitus
  • unwillingness to stay in the area for the whole study period

Trial design

Primary purpose

Educational/Counseling/Training

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

None (Open label)

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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