Metabolic Syndrome and Degenerative Meniscus Lesions Related Knee Function

Yangtze University

Status

Completed

Conditions

Knee Arthritis

Obesity, Abdominal

Meniscus Lesion

Metabolic Syndrome

Treatments

Other: Metabolic syndrome and meniscus injuries

Study type

Observational

Funder types

Other

Identifiers

NCT04921202

Jinzhou Medical University

Details and patient eligibility

About

Studies have suggested that Obese patients with metabolic syndrome(MetS)were correlated with knee joint degeneration and osteoarthritis. However, no studies demonstrate the relationship between obese patients with metabolic syndrome and degenerate meniscus lesions and its knee function.The aim is to detect the correlation between obese patients with metabolic syndrome and degenerate meniscus injuries.

Full description

Obese patients with metabolic syndrome(MetS)were correlated with knee joint degeneration and osteoarthritis. However, no studies demonstrate the relationship between patients with metabolic syndrome and degenerate meniscus lesions or knee function. Participants were recruited from First Affiliated Hospital of Jinzhou Medical University. 100 BMI<24 people without Metabolic syndrome volunteers aged between 35-70 years old and 80 Metabolic syndrome patients with BMI>27 were included in the study. Obese patients with MetS were assessed knee function and degenerate meniscus tears verified by magnetic resonance imaging. And patients with a mild or no osteoarthritis with Kellgren and Lawrence grade<2 verified by X ray. We tested the relationship between metabolic syndrome and degenerate meniscus lesions. Obese patients with MetS and volunteers were detected by Mcmurry's test and MRI image to measure degeneration grade of meniscus tears. Number of MetS components were accounted and the knee function KOOS, IKDC score or degenerate meniscus tears were analyzed.

Enrollment

180 patients

Sex

All

Ages

35 to 70 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Must be age between 35 and 70 years old;
Clinical diagnosis of metabolic syndrome;
BMI score more than 27 or less than 24
Clinical diagnosis of 3 grade degneration meniscus leisons;

Exclusion criteria

Must be able to have no acute knee injury such as car crash or acute sports injury;
Must be able to have no knee surgeries history;
Must be able to have no rheumatoid arthritis or serious knee osteoarthritis with deformity;
Must be able to have no contraindications to MRI;
Must be able to have no severe cardiopulmonary disease;
Must be able to have no musculoskeletal or neuromuscular impairments ;
Must be able to have good visual, hearing, or cognitive;