Metabolic Syndrome and Male Infertility (Metasperme)

Assistance Publique - Hôpitaux de Paris

Status: Completed

Conditions: Male Infertility

Treatments: Other: Blood sample, sperm sample and clinical examens

Study type: Observational

Funder types: Other

Identifiers

NCT01974947

NI 10033

Details and patient eligibility

About

Multidisciplinary, multicentric, cross-sectional study on men in infertile couples who conduct their sperm test through their diagnosis of infertility

Full description

Assessment of sperm parameters and metabolic syndrome relations in men attending a Reproductive Biomedicine centre for an infertility of their couple.

Secondary objectives are to study relationship between sperm parameters and:

• adiposity and insulin resistance
• inflammation
• oxydative stress in blood and semen
• hormonal status Innovative parameters will also be assessed to determine the quality of semen (length of fingers, wrist circumference and epigenetics studies)

Enrollment: 170 patients

Sex: Male

Ages: 18 to 45 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 18 to 45 years-old man
• man consulting for primary or secondary infertility, with or without earlier notion of paternity
• patient insured with a social security scheme
• patient who have had a prior medical consultation
• patient who have done informed and written consent to participate in the research study

Exclusion criteria

• patient with problems understanding French

• patient smoking more than two-pack-a-day

• patient monitoring for viral risk.

• man with an unidiopathic infertility which may be explained by:

  1) identifiable factors in direct questioning at the sperm analysis:

• exposure to toxic products

• infectious disease history

• pathological anatomical background 2) factors identified at the etiologic investigation: cytogenetic and genetic

Trial design

170 participants in 1 patient group

Infertile men

Description:

Man partner of an infertile couple. Blood sample, sperm sample and clinical examens will be done at the day of the inclusion

Treatment:

Other: Blood sample, sperm sample and clinical examens