Metabolism of Omega-3 and Omega-6 During Healthy Aging

Université de Sherbrooke

Status: Completed

Conditions: Healthy Volunteers

Treatments: Other: 13C eicosapentaenoic acid and 13C arachidonic acid

Study type: Observational

Funder types: Other; NETWORK

Identifiers

NCT02957188

13C EPA and 13C AA metabolism

Details and patient eligibility

About

The purpose of this study is to determine the kinetics of 13C-eicosapentaenoic acid (EPA) and 13C-arachidonic acid (AA) in young and older participants

Enrollment: 13 patients

Sex: Male

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• six young (18-30 y old) and six older (≥ 70 y old)
• healthy non medicated participants.

Exclusion criteria

• Tobacco,
• malnutrition (assessed from blood albumin, haemoglobin and lipids), -
• participants taking an EPA+DHA supplements or consuming more than 2 fish meals per week,
• severe gastro-intestinal problems,
• medication for diabetes,
• thyroid disease,
• renal failure,
• cancer,
• psychiatric difficulties or depression,
• cardiovascular disease,
• glucose intolerance (>8 mmol/L in fasted samples)
• chronic immune condition or inflammation (CRP > 10 mg/l, white cell count),
• recent major surgery or cardiac event,
• dementia,
• ongoing or past severe drug or alcohol abuse,
• ongoing or past intensive physical training.

Trial design

13 participants in 2 patient groups

Young

Description:

Six young (18-30 yrs old) healthy participants were recruited. The study had three blocks of one month: 13C-EPA follow-up, wash-out and 13C-AA follow-up. Each participant orally consumed a single oral dose of 35 mg of 13C-EPA, and after the wash-out, a 50 mg dose of 13C-AA.

Treatment:

Other: 13C eicosapentaenoic acid and 13C arachidonic acid

Elderly

Description:

Six older (≥ 70 yrs old) healthy participants were recruited. The study had three blocks of one month: 13C-EPA follow-up, wash-out and 13C-AA follow-up. Each participant orally consumed a single oral dose of 35 mg of 13C-EPA, and after the wash-out, a 50 mg dose of 13C-AA.

Treatment:

Other: 13C eicosapentaenoic acid and 13C arachidonic acid