Metabolism of Patients With Genetically Caused Cardiac Arrhythmia

University of Copenhagen

Status: Unknown

Conditions: Long QT Syndrome

Study type: Observational

Funder types: Other

Identifiers

NCT02775513

LQTS

Details and patient eligibility

About

Loss-of-function mutations in voltage-gated potassium channels cause long QT syndrome (LQTS) due to a prolonged cardiac repolarisation phase. Hypoteses: patients with loss-of-function mutations also exhibit altered hormone release upon glucose ingestion.

Full description

Loss-of-function mutations in voltage-gated potassium channels cause long QT syndrome (LQTS) due to a prolonged cardiac repolarisation phase.

Voltage-gated potassium (Kv-) channels are known for their relation to malignant cardiac arrhythmias, but also play a role in pancreatic alpha- and beta cell hormone secretion, and possibly in incretin hormone secretion. We hypothesised that patients with loss-of-function mutations also exhibit altered hormone release upon glucose ingestion.

Enrollment: 50 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

LQTS Gain of function Matched healthy controls

Exclusion criteria

none

Trial design

50 participants in 2 patient groups

Mutation

Description:

Patients with functional mutation in ion channels

Control

Description:

Matched control