Metabolite Biomarkers Related to Acute Rejection in Kidney Transplantation

Seoul National University

Status: Unknown

Conditions: Kidney Transplantation; Rejection Acute Renal

Study type: Observational

Funder types: Other

Identifiers

NCT03134625

1606-069-771

Details and patient eligibility

About

The development of acute rejection can only be considered in cases with increasing serum creatinine in patients with kidney transplantation. However, the serum creatinine itself is not specific but also accurate for detection of acute rejection. So The specific biomarker is required for acute rejection of kidney transplant. In this study, the investigators will enroll 200 consecutive kidney transplant patients in Seoul National University Hospital and follow up. Serial collection of urine and serum will be done. Acute rejection specific urine metabolite will be found by LC MS/MS.

Enrollment: 200 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Kidney transplant patients in Seoul National University Hospital
• Patients with triple maintenance immunosuppression including Tacrolimus, mycophenolate and steroid

Exclusion criteria

• History of other organ transplantation
• ABOi and/or crossmatch(+) transplantation