Metabolome Analysis in Patients With Rheumatoid Arthritis

The Catholic University of Korea

Status: Unknown

Conditions: RheumatoId Arthritis

Study type: Observational

Funder types: Other

Identifiers

NCT02960958

CiRAD1

Details and patient eligibility

About

The aim of this study is to investigate discriminant metabolites in urine from patients with rheumatoid arthritis (RA) from healthy individuals. Then we determine if the patient's metabolic fingerprint could predict the development or flare-up of RA.

Full description

Compare metabolites between RA patients and healthy individuals.

1. Collection urine sample
2. Assessing urine metabolites by 1H NMR spectroscopy
3. Analyzing the relationships between metabolites and clinical variables

Enrollment: 200 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• All patients with rheumatoid arthritis meet 2010 American College of Rheumatology/European League against Rheumatism classification criteria.

Exclusion criteria

• Comorbid with other autoimmune diseases
• Confirmed with amyloidosis
• Chronic kidney disease (estimated GFR < 60 ml/min/1.73m2)
• Chronic liver disease
• Thyroid disease
• Pregnancy
• Solid tumor/hematologic malignancy within 5 years