Metabolomic Fingerprint After Bariatric Surgery

eSwiss Medical & Surgical Center

Status: Completed

Conditions: Obesity

Treatments: Procedure: bariatric surgery (sleeve resection, proximal RYGB, distal RYGB)

Study type: Observational

Funder types: Other

Identifiers

NCT02480322

Metab-001

Details and patient eligibility

About

Background: Obesity is associated with multiple diseases. Bariatric surgery is the most effective therapy for severe obesity that cannot only reduce body weight but also obesity-associated morbidity.

Objective: The metabolic alterations associated with obesity and respective changes after bariatric surgery are incompletely understood.

Design: In the longitudinal observational study, the investigator applied a 1H-NMR-based global, untargeted metabolomics strategy on human serum samples that were collected before and repeatedly up to one year after distinct bariatric procedures (sleeve gastrectomy, proximal and distal Roux-en Y gastric bypass; RYGB). For comparison, the investigator also analyzed serum samples from normal-weight and less obesity obese subjects that were matched for 1-year postoperative BMI values of the surgical groups.

Enrollment: 106 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• BMI >/=35 kg/m2
• at least 2 years of unsuccessful conservative weight loss attempts

Exclusion criteria

• < 18 years of age
• BMI < 35 kg/m2
• informed consent was not signed by the patient

Trial design

106 participants in 5 patient groups

Sleeve group

Description:

Patients undergoing gastric sleeve resection.

Treatment:

Procedure: bariatric surgery (sleeve resection, proximal RYGB, distal RYGB)

Proximal RYGB group

Description:

Patients undergoing proximal gastric bypass surgery.

Treatment:

Procedure: bariatric surgery (sleeve resection, proximal RYGB, distal RYGB)

Distal RYGB group

Description:

Patients undergoing distal gastric bypass surgery.

Treatment:

Procedure: bariatric surgery (sleeve resection, proximal RYGB, distal RYGB)

BMI-matched control group

Normal-weight control group