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Metabolomic Profile of Patients Undergoing Myocardial Perfusion SPECT (METS)

V

Vall d'Hebron University Hospital (HUVH)

Status

Unknown

Conditions

Ischemic Heart Disease

Treatments

Other: Non intervention

Study type

Observational

Funder types

Other

Identifiers

Details and patient eligibility

About

The aim of this study is to analyze metabolomic pattern of patients after cardiac stress in order to detect differences based on the type of stress (physical or pharmacological with adenosine agonists) and result of test (positive or negative for ischemia) and to indentify biochemical markers with prognostic value. Clinical data of enrolled patients regarding demographics, cardiovascular risk factors, pretest probability and previous cardiovascular disease will be recorded. Follow up will be at one, three and five years and will be performed by clinical recordings or phone call when necessary. Blood samples of patients undergoing myocardial perfusion SPECT (Single Photon Emission Computed Tomography) are taken before, immediately after stress and 2h after stress. Serum samples will be analyzed by nuclear magnetic resonance in order to know metabolomic profile.

Full description

The aim of this study is to analyze metabolomic pattern of patients after cardiac stress in order to detect differences based on the type of stress (physical or pharmacological with adenosine agonists) and result of test (positive or negative for ischemia) and to indentify biochemical markers with prognostic value. Clinical data of enrolled patients regarding demographics, cardiovascular risk factors, pretest probability and previous cardiovascular disease will be recorded. Follow up will be at one, three and five years and will be performed by clinical recordings or phone call when necessary. Blood samples of patients undergoing myocardial perfusion SPECT are taken before, immediately after stress and 2h after stress. Serum samples will be analyzed by nuclear magnetic resonance in order to know metabolomic profile.

Enrollment

500 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Patients men or women ≥ 18 years of age
  • Patients with prescription of cardiac perfusion SPECT

Exclusion criteria

  • Patients with loss of consciousness or confuse, not able to read the information and to sign the writting consent
  • Pregnant women
  • Patients with dobutamine indications in the stress protocol

Trial design

500 participants in 3 patient groups

Patients with Physical Cardiac Stress
Description:
Patients with Physical Cardiac Stress
Treatment:
Other: Non intervention
Patients with Physical and Pharmacological Cardiac Stress
Description:
Patients with Physical and Pharmacological Cardiac Stress with adenosine agonist
Treatment:
Other: Non intervention
Patients with Pharmacological Cardiac Stress
Description:
Patients with Pharmacological Cardiac Stress with adenosine agonist
Treatment:
Other: Non intervention

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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