Metabolomic Profiling of Novel Mediators of Vascular Function

Mass General Brigham

Status: Terminated

Conditions: Type 2 Diabetes Mellitus

Treatments: Procedure: blood sampling and brachial artery ultrasound

Study type: Observational

Funder types: Other

Identifiers

NCT00762242

2007P-000669

Details and patient eligibility

About

The purpose of this study is to identify and characterize specific chemicals and metabolic pathways that change with forearm ischemia. These changes will be compared with forearm blood flow and flow-mediated vasodilation of the brachial artery.

Enrollment: 48 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Adults age 18 or older
• Type 2 diabetes mellitus

Exclusion criteria

• Type 1 diabetes mellitus
• Type 2 diabetics taking insulin, thiazolidinediones (rosiglitazone or pioglitazone), an amylin analog (Symlin [pramlintide]), or incretin mimetics (Byetta [exenatide])
• Pregnancy
• Uncontrolled hypertension, > 180/100 mmHg

Trial design

48 participants in 1 patient group

1

Description:

Blood sampling and brachial artery ultrasound

Treatment:

Procedure: blood sampling and brachial artery ultrasound