Metabolomic Study in Huntington's Disease (METABO-HD)

University Hospital, Angers

Status: Unknown

Conditions: Huntington Disease

Treatments: Biological: blood sample

Study type: Interventional

Funder types: Other

Identifiers

NCT03296176

49RC17_0086

Details and patient eligibility

About

The purpose of this project is to study Huntington's disease by metabolomic approach.

Enrollment: 150 estimated patients

Sex: All

Ages: 20 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

For all groups:

• age between 20 and 70 years
• signature of the informed consent
• covered by social security

For presymptomatic group:

• positive genetic test with CAG repeat length ≥ 37 in HTT gene
• Unified Huntington Disease Rating Scale ≤ 5

For symptomatic group:

• positive genetic test with CAG repeat length ≥ 37 in HTT gene
• The Unified Huntington's Disease Rating Scale motor score ≥ 6
• The Total Functional Capacity score ≥ 11

Exclusion Criteria for all groups:

• participation in another therapeutic trial (3 months exclusion period)
• pregnancy and breastfeeding
• persons deprived of their liberty by judicial or administrative decision

Trial design

Primary purpose: Other

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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150 participants in 3 patient groups

presymptomatic

Experimental group

Treatment:

Biological: blood sample

symptomatic

Experimental group

Treatment:

Biological: blood sample

controls

Other group

Treatment:

Biological: blood sample