Metabolomics and Microbiomics in Cardiovascular Diseases (MEMORIA)

Universitätsmedizin Mannheim

Status: Unknown

Conditions: NSTEMI - Non-ST Segment Elevation MI; Myocardial Infarction, Acute; Acute Heart Failure; STEMI - ST Elevation Myocardial Infarction; Cardiomyopathies; Dilated Cardiomyopathy; Ischemic Cardiomyopathy; Sepsis

Treatments: Other: Blood draw

Study type: Observational

Funder types: Other

Identifiers

NCT04146701

2019-1093N-MA

Details and patient eligibility

About

"MEtabolomics and MicrObiomics in caRdIovAscular diseases Mannheim (MEMORIAM) " is a single-center, prospective and observational study investigating to identify disease-specific metabolic, respectively microbiomic, patterns of patients with high-risk cardiovascular diseases. High-risk cardiovascular diseases comprise patients suffering from acute heart failure (AHF), ST-segment elevation myocardial infarction (STEMI), non-ST-segment elevation myocardial infarction (NSTEMI), sepsis, septic shock, ischemic and non-ischemic cardiomyopathy.

Full description

Scientific evidence about the metabolomic and microbiomic changes in high-risk cardiovascular patients is still lacking.

The acute, critical or progressive disease status predestinies to relevant changes in cardiovascular metobolism. High-risk patients in the present trial comprise those with acute heart failure, myocardial infarction (STEMI and NSTEMI), sepsis, septic shock, ischemic and non-ischemic cardiomyopathy with severely reduced left ventricular ejection fraction (LVEF <35%).

Therfore this study investigates to identify disease-specific patterns of metabolic and microbiomic changes. These patterns may help to understand pathophysiology at the metabolic stages and find out those patients being at highest risk of adverse future outcome.

Enrollment: 750 estimated patients

Sex: All

Ages: 18 to 100 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• above mentioned diseases, diagnosis according to respective guideline
• written informed consent

Exclusion criteria

• under 18 years
• cancer
• rheumatic diseases
• infections (except septic group)
• higher grade heart valve diseases

Trial design

750 participants in 7 patient groups

Acute heart failure

Description:

All consecutive patients admitted with acute heart failure to University Medical Center Mannheim. One venous blood withdraw will be performed. Demographic and clinical data will be documented.

Treatment:

Other: Blood draw

STEMI

Description:

All consecutive patients admitted with STEMI to University Medical Center Mannheim. One venous blood withdraw will be performed. Demographic and clinical data will be documented.

Treatment:

Other: Blood draw

NSTEMI

Description:

All consecutive patients admitted with NSTEMI to University Medical Center Mannheim. One venous blood withdraw will be performed. Demographic and clinical data will be documented.

Treatment:

Other: Blood draw

Ischemic cardiomyopathy

Description:

All consecutive patients with an implantable cardioverter defibrillator (ICD) due to ischemic cardiomyopathy and LVEF \<35% presenting for ICD check-up to University Medical Center Mannheim. One venous blood withdraw will be performed. Demographic and clinical data will be documented.

Treatment:

Other: Blood draw

Non-ischemic cardiomyopathy

Description:

All consecutive patients with an implantable cardioverter defibrillator (ICD) due to non-ischemic cardiomyopathy and LVEF \<35% presenting for ICD check-up to University Medical Center Mannheim. One venous blood withdraw will be performed. Demographic and clinical data will be documented.

Treatment:

Other: Blood draw

Sepsis

Description:

All consecutive patients admitted with sepsis or septic shock to University Medical Center Mannheim. One venous blood withdraw will be performed. Demographic and clinical data will be documented.

Treatment:

Other: Blood draw

Healthy controls

Description:

Clinically inapparent group as controls. One venous blood withdraw will be performed. Demographic and clinical data will be documented.

Treatment:

Other: Blood draw