Metabolomics in Assessing the Quality of Kidney Transplants Retained on a LifePort® Perfusion Machine (RENALIFE)

Regional University Hospital Center (CHRU)

Status: Completed

Conditions: Renal Transplantation

Treatments: Device: LifePort® perfusion machine

Study type: Interventional

Funder types: Other

Identifiers

NCT03024229

PHAO15/FB-RENALIFE

Details and patient eligibility

About

When the kidneys are perfused on perfusion machines before transplantation, the resistance parameters as well as the histological score on the pre-implantation biopsy participate in the evaluation of the quality of the graft. The metabolomic profile of the infusion fluid could provide additional evidence.

Full description

The quality of the renal transplant prior to transplantation is essential for the recovery of graft function in the days following transplantation and its long-term survival. When the kidneys are perfused on perfusion machines before transplantation, the resistance parameters as well as the histological score on the pre-implantation biopsy participate in the evaluation of the quality of the graft. The metabolomic profile of the infusion fluid could provide additional evidence.

Enrollment: 40 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Donors aged 18 years or more in brain death or who died of cardiac arrest collected locally in Tours, associated with the major local recipients of the grafts over the same period.

Exclusion criteria

• Kidney transplant removed but stored in a static preservative.
• Kidney grafts of donors aged 18 years or more, removed and not retained on a LifePort® perfusion machine.

Trial design

Primary purpose: Health Services Research

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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40 participants in 1 patient group

LifePort® perfusion machine

Other group

Description:

Metabolomic analysis of the preservation fluid of the graft, donor and recipient urine by nuclear magnetic resonance spectroscopy, and if possible by liquid and gas chromatography coupled with mass spectrometry.

Treatment:

Device: LifePort® perfusion machine