Metabolomics in Occupational Asthma

University of Oslo (UIO)

Status: Enrolling

Conditions: Asthma, Occupational

Treatments: Device: Breath Biopsy

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT04301674

UO1

Details and patient eligibility

About

The project aims to increase the diagnostic accuracy in occupational asthma (OA), with emphasis on Irritant Induced Asthma (IIA). Currently, most patients are evaluated in occupational medicine by comparing the exposure and symptom characteristics with epidemiological data. Biological markers may be present in AA, but presently not in IIA. The majority of cases evaluated are considered as possible IIA, i.e. low-dose multiple exposures. VOC features will be analyzed with the Breath Biopsy® and TD-GS-MS (Owlstone Medical Ltd, UK).

Enrollment: 80 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• capable of informed consent.
• asthma diagnosis established by lung specialist or healthy control.

Exclusion criteria

• skin allergy towards plastics or rubber.
• immunocompromised by oral medication.
• contagious respiratory disease.
• biopsy of lung parenchyma within the last 36 hours.

Trial design

80 participants in 2 patient groups

Occupational Asthma

Description:

Patients refered for assesment of occupational asthma

Treatment:

Device: Breath Biopsy

Respiratory Healthy Control

Description:

Employees at Oslo University Hospital

Treatment:

Device: Breath Biopsy