Metabolomics Study on Intensive Care Acquired Muscle Weakness in Polytrauma (MIRACLE II)

Technical University of Munich

Status: Completed

Conditions: Critical Care; Metabolomics; Critical Illness; Muscle Weakness; Critical Illness Polyneuropathy; Critical Illness Myopathy; Intensive Care (ICU) Myopathy

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT03819959

MIRACLE II

Details and patient eligibility

About

In this mono-center pilot trial, polytrauma patients admitted to intensive care will be included. Investigators are going to take blood and muscle samples at respecified time points to do metabolic, histological and molecular testing.

Aim of the study is to investigate (1) changes of the blood metabolome in patients with ICUAW (intensive care unit acquired weakness) and (2) identify metabolic components who are responsible for ICUAW or can be used as marker for ICUAW.

Enrollment: 10 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• acute polytrauma patient
• age ≥ 18 years old
• expected intensive care stay ≥ 3 days
• American Society of Anesthesiologists classification I or II

Exclusion criteria

• patient had received cardiopulmonary resuscitation
• limitation of therapy or comfort care

Trial design

10 participants in 1 patient group

Intensive Care Patients

Description:

Polytrauma patients who have been admitted to intensive care