Metabolomics Study on Postoperative Intensive Care Acquired Muscle Weakness (MIRACLE I)

Technical University of Munich

Status: Enrolling

Conditions: Critical Care; Metabolomics; Critical Illness; Muscle Weakness; Critical Illness Polyneuropathy; Critical Illness Myopathy; Intensive Care (ICU) Myopathy

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT03810768

MIRACLE I

Details and patient eligibility

About

In this mono-center pilot trial, surgical patients who are at high risk to be admitted to intensive care will be screened and asked for participation. We are going to take blood and muscle samples at respecified time points to do metabolic, histological and molecular testing.

Aim of the study is to investigate (1) changes of the blood metabolome in patients with ICUAW (intensive care unit acquired weakness) and (2) identify metabolic components who are responsible for ICUAW or can be used as marker for ICUAW.

Enrollment: 20 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• invasive mechanically ventilated critically ill patient with expected intensive care unit stay > 3 days
• postoperative patient
• ≥ 18 years old
• American Society of Anesthesiology (ASA) classification ≥ III

Exclusion criteria

• moribund patient
• non-curative care (comfort care)

Trial design

20 participants in 2 patient groups

Intensive Care Patients

Description:

Postoperative high-risk patients who have been admitted to intensive care after surgery

Operative Control patients

Description:

Elective operative patients where control blood samples and muscle ultrasound will be measured.