Metagenomic Analysis of Gut Microbiome in Korean Patients With Ulcerative Colitis

Seoul National University

Status: Unknown

Conditions: Ulcerative Colitis

Treatments: Procedure: Colonoscopy biopsy; Other: stool collection; Procedure: colonoscopy biopsy

Study type: Observational

Funder types: Other

Identifiers

NCT01010815

Gut Microbiome in UC Patients

Details and patient eligibility

About

The researchers will investigate gut microbiome in Korean patients with ulcerative colitis and normal control subjects using metagenomic analysis to elucidate the significant difference between two groups This study will help to understand the association between gut microbiome and inflammatory bowel disease.

Enrollment: 15 estimated patients

Sex: All

Ages: 19 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Between the age of 19 and 75 years
• willing to consent/undergo necessary procedures
• clinically active or inactive Ulcerative colitis

Exclusion criteria

• Inability to provide informed consent or
• Clinically severe or fulminant ulcerative colitis
• Previous abdominal surgery
• Pregnancy
• Clinically or laboratory-confirmed gastroenteritis for at least 3 months before sampling
• the use of antibiotics in the past a month before sampling
• the use of probiotics in the past a month before sampling
• Severe cardiovascular or pulmonary disease
• Severe convulsive disorder and current use of anti-convulsive medication
• Malignancy
• Transplantation

Trial design

15 participants in 2 patient groups

UC group

Description:

clinically and microscopically confirmed UC patients between the age of 19 and 75 years

Treatment:

Other: stool collection

Other: stool collection

Procedure: colonoscopy biopsy

Control group

Description:

normal healthy controls

Treatment:

Procedure: Colonoscopy biopsy

Other: stool collection

Other: stool collection