Metagenomic Analysis of Gut Microbiome in Preterm (MAGMP)

Wonju Severance Christian Hospital

Status

Unknown

Conditions

Microbial Substitution

Microbial Colonization

Newborn Morbidity

Microbial Superinvasion

Study type

Observational

Funder types

Other

Identifiers

NCT03235635

microbiome in nicu

Details and patient eligibility

About

This is single center study. The investigators will try to know that relationships between intestinal microbiome and mortality in preterm infants and what relationships is between intestinal microbiome in preterm infants and morbidity, mortality.

Full description

Microbiome is the collection of all the microorganisms living in association with the human body which are consist of eukaryotes, archaea, bacteria and viruses. Microbiome in an average human body number are ten times more than human cells and have about 1000 more genes than are present in the human genome. There are symbiotic relationships between human and microbiome. If investigators are able to know about relationships between newborn and intestinal microbiome, mortality and morbidity in preterm infants may be improved. The investigators will collect the first and weekly stool of participants and analyze DNA of microbiome thorough Metagenomic anlysis. The results between 3 groups(preterm, late preterm and full-term infants) will be compared. The investigators expect that a mean distribution of intestinal microbiome in newborns(preterm, late preterm and full-term) is defined and that relationships between mortality, morbidity and intestinal microbiome.

Enrollment

120 estimated patients

Sex

All

Ages

1 to 1 day old

Volunteers

No Healthy Volunteers

Inclusion criteria

preterm infants who were born at gestational age of less than 36 weeks from approval date to Feb 28th 2019
full-term infants who were born at gestational age of greater than 37 weeks from approval date to Feb 28th 2019

Exclusion criteria