Meteorin-like Levels in Individuals With Periodontitis

Istanbul Saglik Bilimleri University

Status: Completed

Conditions: Periodontitis; Healthy; Gingivitis

Treatments: Other: Saliva; Other: gingival crevicular fluid

Study type: Observational

Funder types: Other

Identifiers

NCT04402996

Sağlık Bilimleri Üniversitesi

Details and patient eligibility

About

Metrnl has proven to be an inflammatory-related immunoregulatory cytokine and shown to play a role in the pathogenesis of human inflammatory diseases. Metrnl is highly expressed from the oral mucosa to the esophagus. Periodontitis is a chronic inflammatory disease that can start with localized inflammatory reactions created by the supporting tissues surrounding the teeth against microorganisms and then result in loss of teeth. The authors think that Metrnl may play a role in the periodontitis. The aim of this study is to compare the Metrnl, IL-1β, and IL-10 levels of healthy and periodontitis individuals.

Full description

Periodontitis is a destructive chronic inflammatory disease that can start with localized inflammatory reactions created by the supporting tissues surrounding the teeth against microorganisms and then result in loss of teeth. Cytokines play an important role in inflammation that occurs in periodontal disease.

Interleukine -1β ( IL-1β ) levels are associated with periodontal destruction in the pathogenesis of periodontal disease. Cytokines such as Interleukine-10 (IL-10) and transforming growth factor- β (TGF-β) have been reported to decrease periodontal disease progression rate.

Gingival crevicular fluid shows the cellular response in the periodontium. The most important host-related ingredients are inflammatory markers, including cytokines, enzymes, and interleukins. Saliva analysis is used in the diagnosis of systemic conditions as well as in the diagnosis of oral pathologies.

Meteorin- like (Metrnl) is a protein that plays a role in natural and acquired immune-related functions and inflammatory responses, and expressed in barrier tissues (skin and mucosa) as well as various macrophage populations, from dendritic cells and some granulocytes. Metrnl has proven to be an inflammatory-related immunoregulatory cytokine and shown to play a role in the pathogenesis of human inflammatory diseases. Metrnl, which is highly expressed from the oral mucosa to the esophagus, may play a role in the onset of periodontitis and an effective marker in preventing the progression of destruction. We think that Metrnl plays an important role in periodontitis, an inflammatory disease. The aim of this study is to compare the Metrnl, IL-1β, and IL-10 levels of healthy and periodontitis individuals

Enrollment: 60 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• systemically healthy
• individuals who does not have a disease under treatment,
• individuals without regular systemic medication

Exclusion criteria

• smoking
• receiving periodontal treatment in the last 6 months
• pregnancy
• menopausal or menstrual period

Trial design

60 participants in 3 patient groups

Healthy

Description:

Individuals with Periodontally Healthy

Treatment:

Other: gingival crevicular fluid

Other: Saliva

Gingivitis

Description:

Individuals with Gingival Inflammation

Treatment:

Other: gingival crevicular fluid

Other: Saliva

Periodontitis

Description:

Individuals with Periodontitis

Treatment:

Other: gingival crevicular fluid

Other: Saliva