Metformin for Treatment Antipsychotic Induced Amenorrhea in Female Schizophrenic Patients

Central South University

Status and phase: Completed; Phase 4

Conditions: Amenorrhea

Treatments: Drug: metformin

Study type: Interventional

Funder types: Other

Identifiers

NCT01206153

RWu

Details and patient eligibility

About

Antipsychotics such as risperidone could induce amenorrhea in schizophrenic patients. The investigators conducted a randomized, placebo-controlled study to test the efficacy of metformin for antipsychotic induced amenorrhea in schizophrenia patients.

Enrollment: 84 patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• schizophrenia patient
• amenorrhea for more than three months after antipsychotic treatment

Exclusion criteria

• liver or renal diseases
• pregnant or lactating women
• cardiovascular diseases
• hypertension or diabetes mellitus

Trial design

84 participants in 1 patient group

metformin

Experimental group

Treatment:

Drug: metformin