Metformin in Combined With Cisplatin Plus Paclitaxel With Advanced Esophageal Squamous Cell Carcinoma (ECMTPneo)

Peking University

Status and phase

Unknown

Phase 2

Conditions

Esophageal Squamous Cell Carcinoma

Treatments

Drug: metformin and chemotherapy

Study type

Interventional

Funder types

Other

Identifiers

NCT03833466

ESCC-MTPneo

Details and patient eligibility

About

This is an open-label phase II trial investigating the effect of metformin in combined with cisplatin plus paclitaxel as neoadjuvant therapy with advanced esophageal squamous cell carcinoma.

Full description

In this prospective phase II study, eligible patients are received cisplatin plus paclitaxel for 2-4 cycles combined with metformin orally. The investigators aim to compare the tumor metabolic pathway and tumor microenvironment of pre-chemotherapy endoscopic biopsy samples and post-chemotherapy surgical resection samples.

Enrollment

15 estimated patients

Sex

All

Ages

18 to 70 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Having signed informed consent.
Age 18 to 70 years old
Histologically confirmed esophageal squamous carcinoma
Computed tomography (CT) or magnetic resonance imaging (MRI) confirmed advanced ESCC which need neoadjuvant chemotherapy before surgical resection.
Measurable disease according to the Response Evaluation Criteria In Solid Tumors (RECIST) 1.1 criteria(diameter of the lesion should be more than 10mm by spiral CT or MRI, more than 20mm by common CT, the date of image should be less than 21 days before enrollment)
Life expectancy of ≥3 month
Eastern Cooperative Oncology Group (ECOG) 0-1
Body Mass Index (BMI) ≥18.5kg/m2
WBC>3,000/mm3, absolute neutrophil count ≥1500/mm3, platelet>100,000/mm3, Hb>9g/dl，Bilirubin level < 1.5 times ULN，Serum creatinine <1.5 times ULN，ALT and AST<2.5 times ULN ，AKP < 2.5 times ULN ，(≤5 times ULN in patients with liver metastases)(within 7 days before enrollment)
No sever complication, such as active gastrointestinal bleeding, perforation, jaundice, obstruction, non-cancerous fever>38℃.
Good compliance

Exclusion criteria

Have used metformin or biguanide in the past
Contraindications of metformin
Unable to take metformin orally because of esophageal stenosis
Currently receiving other effective regimens
Previous anticipate other clinical trial within 4 weeks before entering this study
No measurable lesions, eg. pleural fluid and ascites\
Only with other previous malignancy within 5 year, except non-melanoma skin cancer and cervical carcinoma in situ
Heart failure or other sever organ dysfunction, eg. coronary artery disease, myocardial infarction within the last 6 months only Brain or bone metastasis
Mentally abnormal or disable cognition,including central nervous system (CNS) metastasis
HIV infection, active hepatitis B or hepatitis C
Unstable systemic diseases such as poorly controlled diabetes
Interstitial lung disease, such as interstitial pneumonia, pulmonary fibrosis, or evidence of interstitial lung disease showed in X-ray/CT
Known hypersensitivity to study drugs
Pregnancy or lactation period