Methadone in Post-Herpetic Neuralgia Pain (NPH)

University of Sao Paulo

Status and phase: Completed; Phase 3

Conditions: Post-herpetic Neuralgia

Treatments: Drug: Placebo; Drug: Methadone

Study type: Interventional

Funder types: Other

Identifiers

NCT01752699

NPH

Details and patient eligibility

About

Neuropathic pain is a common condition and affecting 40 to 70% of the general population. Post-herpetic neuralgia is a condition almost complex and requires a multi modal treatment. Aim: This is a pilot proof-of-principle study designed to evaluate the use of low-dose methadone in post-herpetic neuralgia patients who remained refractory after first and second line treatment for post-herpetic neuralgia (PHN) and had indication for the association of an opioid agent to their current drug regimen.

Enrollment: 10 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with chronic (>6 months) symptomatic PHN
• with visual analogical scale >40/100mm
• use of first and second line drugs (tricyclic antidepressants, venlafaxine and gabapentinoids)

Exclusion criteria

• Don't full the criteria above

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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10 participants in 2 patient groups

Methadone

Experimental group

Description:

in this arm patients will take methadone 5mg.

Treatment:

Drug: Methadone

Placebo

Experimental group

Description:

in this arm patients will take placebo pills.

Treatment:

Drug: Placebo