Methemoglobinemia in Young Patients With Hematologic Cancer or Aplastic Anemia Treated With Dapsone

Vanderbilt University

Status: Completed

Conditions: Multiple Myeloma and Plasma Cell Neoplasm; Nonmalignant Neoplasm; Methemoglobinemia; Lymphoproliferative Disorder; Chronic Myeloproliferative Disorders; Lymphoma; Leukemia; Myelodysplastic Syndromes; Myelodysplastic/Myeloproliferative Neoplasms

Treatments: Other: medical chart review; Drug: dapsone; Procedure: assessment of therapy complications; Drug: chemotherapy

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT00993694

P30CA068485 (U.S. NIH Grant/Contract)

IRB# 090009

CDR0000652603

VU-VICC-PED-0916

Details and patient eligibility

About

RATIONALE: Gathering information about how often methemoglobinemia occurs in young patients receiving dapsone for hematologic cancer or aplastic anemia may help doctors learn more about the disease and plan the best treatment.

PURPOSE: This research study is looking at methemoglobinemia in young patients with hematologic cancer or aplastic anemia treated with dapsone.

Full description

OBJECTIVES:

• Define the incidence of methemoglobinemia in patients with hematologic malignancy or aplastic anemia who received dapsone prophylaxis through a retrospective chart review encompassing the last 15 years.
• Identify major risk factors for developing methemoglobinemia.

OUTLINE: Medical charts are reviewed. Of particular interest is demographic information, reasons for beginning dapsone prophylaxis, duration of dapsone prophylaxis, dapsone dosing, methemoglobin level, and treatment with methylene blue.

Enrollment: 41 patients

Sex: All

Ages: Under 18 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

DISEASE CHARACTERISTICS:

• Diagnosis of hematologic malignancy or aplastic anemia

  • Treated within the past 15 years with dapsone prophylaxis during treatment of primary disease

PATIENT CHARACTERISTICS:

• Not specified

PRIOR CONCURRENT THERAPY:

• See Disease Characteristics