Methods for Objective Selection of Competent Sperm (MACS)

Instituto Valenciano de Infertilidad, IVI VALENCIA

Status: Completed

Conditions: Sperm Selection

Treatments: Other: Negative selection

Study type: Interventional

Funder types: Other

Identifiers

NCT01265329

0810-C-051-MM

Details and patient eligibility

About

In spite of the achievements and developement of the assisted reproduction techniques in the last years, there is still an elevated percentage of unsuccessful treatments, needing sometimes repeated attempts to reach pregnancy.

The molecular physiology of sperm is being better characterized, and some reports have demonstrated the implication of different molecular processes in the pathophysiology of male infertility.

Recently, different sperm selection methods have been based on these molecular differences, showing a better quality of the sperm population after selection.

The main objective of this research project is to clinically apply these techniques in order to increase the pregnancy rates per cycle in infertile couples attending assisted reproduction treatments.

Enrollment: 237 patients

Sex: All

Ages: 18 to 37 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

MEN:

• >3million sperm after swimming process

WOMEN:

• < 37 YEARS OLD
• NO GYNECOLOGICAL ANOMOLIES
• HORMONAL VALUES WITHIN CLINICAL RANGE

Exclusion criteria

• NONE

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

---

237 participants in 2 patient groups

Control

No Intervention group

Description:

No sperm selection

Annexine V negative

Experimental group

Description:

Sperm selection with Annexine V protein

Treatment:

Other: Negative selection