Methotrexate Iontophoresis Versus Coal Tar Ointement in the Treatment of Primary Palmer Hyper Hidrosis

Cairo University (CU)

Status: Not yet enrolling

Conditions: Iontophore; Hyperhidrosis

Treatments: Other: Iontophoresis with coal tar ointement; Other: Iontophoresis with methotrexate

Study type: Interventional

Funder types: Other

Identifiers

NCT05875285

Nayera_Radwan_2023

Details and patient eligibility

About

The purpose of the study is to compare the therapeutic effect of methotrexate iontophoresis versus coal tar ointment on the the treatment of primary palmer hyperhidrosis?

Full description

Some researchers stated that hyperhidrosis can render the skin susceptible to infection because of the continuous dampness of the skin. The condition may become socially, psychologically and professionally debilitating.

There are a lot of literatures concerned with studying the modalities used in the treatment of primary palmar hyperhidrosis, so this study will be conducted to compare between two of them and to show the best one for treating primary palmar hyperhidrosis.

Enrollment: 60 estimated patients

Sex: All

Ages: 15 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patient with primary palmar hyperhidrosis to extend that their palms are wet during most of the day (score 3 and 4 in the Hyperhidrosis Disease Severity Scale) was included in this study.
• The palmer hyperhidrosis patient's age ranged from 15 to 35 years.
• All patients will be examined by dermatologist before starting the study.

Exclusion criteria

The study excluded the following patients:

• Patients with medical conditions that associated with hyperhidrosis are excluded, these conditions include:- hyperthyroidism, diabetes mellitus, parkinsonism, spinal cord injury, brain damage, congestive heart failure, anxiety, alcoholism and menopause.
• Patients who received any treatment with a drug that was affecting sweating e.g. (thyroxin, anxiolytics.....) that is not stopped at least 4 weeks preceding the study.
• Patients with cardiac conditions such as arrhythmia, ischemic heart disease, low exercise tolerance, low respiratory reserve were excluded.
• Patients, who have a local wound, sever eczema and severe fungal infection of the palms to minimize risk of local burn.
• Patients who have sensory disorders.
• Female patients who are pregnant and lactating.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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60 participants in 2 patient groups

Methotreaxate iontophoresis

Experimental group

Description:

Thirty patients of both sexes of primary palmar hyperhidrosis are selected to participate in this group from EL KASR EL- AINI

Treatment:

Other: Iontophoresis with methotrexate

Coal tar ointment

Experimental group

Description:

Thirty patients of both sexes of primary palmar hyperhidrosis are selected to participate in this group from EL KASR EL- AINI

Treatment:

Other: Iontophoresis with coal tar ointement