Methylation Level of SHOX2 in Endobronchial Ultrasound With Real-time Guided Transbronchial Needle Aspiration for Lung Cancer Staging

University Hospital Essen

Status: Completed

Conditions: Lung Cancer With Mediastinal Lymph Node Involvement

Treatments: Other: No intervention

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT01653002

11-4921-BO (Other Identifier)

RLK-Epi-1

Details and patient eligibility

About

A DNA hypermethylation of the gene locus SHOX2 can be frequently found in lung cancer tissue. The purpose of this study is to determine whether the assessment of the hypermethylation level of SHOX2 in specimens obtained by endosonographic guided bronchoscopy makes a contribution to lung cancer staging.

Enrollment: 200 patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• clinical diagnosis of lung cancer
• enlarged mediastinal or hilar lymph nodes (>10 mm)

Exclusion criteria

• clinical condition which excludes general anesthesia

Trial design

200 participants in 1 patient group

Lung cancer with lymph node involvement

Treatment:

Other: No intervention