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About
42 patients admitted in ICU with intolerance to enteral feeding (GRV more than 250 ml) are recruited. All patients enter a primary acetaminophen absorption test study as baseline. Serum levels of acetaminophen will be measured by florescence polarization method at 15,30,45,60,90,120,180,240,480 minutes after enteral administration of 975 mg acetaminophen. Then the patients will be randomized to methylnaltrexone or erythromycin group.Another acetaminophen absorption test with the same schedule will be done after the last dose of each drug.The area under the curve for acetaminophen blood level will be used to compare the effect of two studied drugs on gastric emptying time.
Enrollment
Sex
Ages
Volunteers
Inclusion criteria
Exclusion criteria
Receiving the study drugs or metoclopramide within 24 hours of inclusion
Known allergy to interventional drugs or acetaminophen
Gastrointestinal bleeding or surgery on GI system within 24 hours of inclusion
Crohn's disease
GI perforation or obstruction
Short bowel syndrome
Liver failure or 2 of the followings:
Patients on hemodialysis or CRRT
Hemodynamically unstable patients including:
Documented or suspected pregnancy
Obesity; actual body weight more than 1.5 times ideal body weight
Myasthenia Gravis.
Opioid drug abuse
Primary purpose
Allocation
Interventional model
Masking
42 participants in 2 patient groups
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Data sourced from clinicaltrials.gov
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