Metoclopramide on Gastric Emptying in Mechanically Ventilated Patients

Tanta University

Status and phase: Completed; Phase 4

Conditions: Gastric Emptying; Randomized Controlled Trial; Metoclopramide; Mechanically Ventilation

Treatments: Drug: Metoclopramide; Drug: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT05641051

35298/2/22

Details and patient eligibility

About

The aim of this study is to evaluate the prokinetic effect of metoclopramide on gastric emptying in critically ill mechanically ventilated patients .

Full description

More than 50% of patients in ICU have gastric dysmotility, which leads to slow gastric emptying(GE) and high gastric residual volume (GRV) and is associated with increased mortality in these patients

Enrollment: 80 patients

Sex: All

Ages: 20 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Patients' age 20 - 60 years.
2. Either gender.
3. Mechanically ventilated head trauma patients.
4. Patients receiving enteral feeding via nasogastric tube.

Exclusion criteria

1. Patients with contraindications to enteral feeding.
2. Patients with extrapyramidal manifestations.
3. Patients with known allergy to metoclopramide.
4. Patients with seizures.
5. Patients with renal or hepatic diseases.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

---

80 participants in 2 patient groups, including a placebo group

Metoclopramide group

Experimental group

Description:

Patients will receive 10 mg intravenous metoclopramide / 6 hours.

Treatment:

Drug: Metoclopramide

Control group

Placebo Comparator group

Description:

Patients will receive the same volume of intravenous placebo / 6 hours.

Treatment:

Drug: Placebo