Metoclopramide-Ondansetron vs. Metoclopramide Therapy for Treatment of Nausea and Vomiting Post Laparoscopic Surgery

Makassed General Hospital

Status: Completed

Conditions: Postoperative Nausea and Vomiting

Treatments: Other: General anesthesia; Other: Dual therapy; Other: Monotherapy

Study type: Interventional

Funder types: Other

Identifiers

NCT03459248

122018

Details and patient eligibility

About

The incidence of postoperative nausea and vomiting (PONV) after general anesthesia is up to 30% when inhalational anesthetics are used with no prophylaxis. This makes PONV one of the most common complaints following surgery under general anesthesia, together with postoperative pain.

Full description

This is a prospective, randomized, double-blind controlled clinical trial. Written informed consent will be obtained from patients. Patients will be randomly assigned using the sealed envelope technique into 2 equal groups:

Group 1: Patients will receive 10 mg metoclopramide with 4mg ondansetron before induction of general anesthesia.

Group 2: Patients will receive 10 mg metoclopramide before induction of general anesthesia.

Enrollment: 120 patients

Sex: All

Ages: 16+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients aging 16 years and above
• Patients undergoing laparoscopic cholecystectomy under General Anesthesia at Makassed General Hospital

Exclusion criteria

• Patients with history of motion sickness
• Patients on previous treatment by anti-emetics for dizziness, vertigo or other causes of nausea and vomiting
• Patients with any type of allergy to metoclopramide or ondansetron
• Patients refusing to be part of the study (refusal to sign consent)
• Patients on previous treatment by opioids

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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120 participants in 2 patient groups

Dual therapy

Experimental group

Description:

Patients will receive 10 mg metoclopramide with 4mg ondansetron before induction of general anesthesia

Treatment:

Other: General anesthesia

Other: Dual therapy

Monotherapy

Active Comparator group

Description:

Patients will receive 10 mg metoclopramide before induction of general anesthesia.

Treatment:

Other: General anesthesia

Other: Monotherapy