Metoclopramide Versus Ketorolac for Tension-type Headache

Montefiore Medicine Academic Health System

Status and phase: Completed; Phase 4

Conditions: Headache

Treatments: Drug: Metoclopramide; Drug: Ketorolac

Study type: Interventional

Funder types: Other

Identifiers

NCT01011673

09-08-249

Details and patient eligibility

About

Occasionally, episodic tension-type headache may be severe enough to require an emergency department (ED) visit. The purpose of this study is to compare two commonly used medications to see which is better for tension type headache. Patients who present to the ED with an acute tension-type headache requiring treatment with injectable medication will be randomized to metoclopramide or ketorolac.

Enrollment: 123 patients

Sex: All

Ages: 21 to 64 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Acute tension type headache

Exclusion criteria

• Contraindications to investigational medications
• Secondary cause of headache

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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123 participants in 2 patient groups

Ketorolac

Active Comparator group

Description:

Ketorolac 30mg IVSS

Treatment:

Drug: Ketorolac

Metoclopramide

Active Comparator group

Description:

metoclopramide 20mg IVSS + diphenhydramine 25mg IVSS

Treatment:

Drug: Metoclopramide