MgSO4 Combined With Rocuronium Priming

Seoul National University

Status: Unknown

Conditions: Muscle Relaxation

Treatments: Drug: magnesium sulfate; Drug: priming; Drug: magnesium sulfate and priming

Study type: Interventional

Funder types: Other

Identifiers

NCT01389791

Mg priming

Details and patient eligibility

About

Priming with either rocuronium or MgSO4 is known to accelerate the effect of rocuronium on muscle relaxation. The purpose of this study is to define the effect of MgSO4 on the rocuronium-priming.

Full description

Acceleration of muscle relaxation is beneficial in rapid-sequence intubation. If MgSO4 combined with priming is efficient in accelerating muscle relaxation, it would be an interesting alternative to rapid-sequence intubation.

Enrollment: 100 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients of ASA Ⅰ-Ⅱ
• aged 18~65
• scheduled to undergo elective surgery under general anesthesia

Exclusion criteria

• risk of pulmonary aspiration
• anticipated airway difficulty
• reactive airway disease
• allergic to study drugs
• neuromuscular / cardiovascular/ renal/ hepatic disease
• atrioventricular conduction disturbance
• BMI < 18.5 or > 24.9
• chronic treatment with calcium channel blocker
• medications which affect muscle relaxation

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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100 participants in 4 patient groups

Roc

No Intervention group

Description:

Patients in this group receive neither MgSO4 nor priming dose of rocuronium.

priming

Active Comparator group

Description:

patients in this group receive 0.06mg/kg of rocuronium before 0.54mg/kg of rocuronium.

Treatment:

Drug: priming

Mg&priming

Experimental group

Description:

Patients in this group receive MgSO4 50mg/kg and 0.06mg/kg of rocuronium before administration of 0.54mg/kg of rocuronium.

Treatment:

Drug: magnesium sulfate and priming

MgSO4

Active Comparator group

Description:

Patients in this group receive intravenous MgSO4 before administration of rocuronium.

Treatment:

Drug: magnesium sulfate