Micellar Water and the Skin Barrier: Comparing Rinsing vs. Non-Rinsing Application

University of Split

Status: Active, not recruiting

Conditions: Effects of Micellar Water Application on Skin Barrier Integrity, Hydration, and Erythema in Healthy Skin

Treatments: Procedure: Micellar Water Application (No Rinse); Procedure: Micellar Water Application (With Rinse)

Study type: Interventional

Funder types: Other

Identifiers

NCT07079371

2181-198-03-04-25-0065

Details and patient eligibility

About

The goal of this clinical trial is to assess how micellar water affects the skin barrier in healthy adult volunteers. The main questions it aims to answer are:

• Does leaving micellar water on the skin affect skin barrier function differently than rinsing it off?
• Are there measurable differences in transepidermal water loss (TEWL), skin hydration, and erythema between the two application methods?

Researchers will compare the effects of micellar water left on the skin versus rinsed off after application.

Participants will:

• Be randomly assigned to one of two groups
• Apply micellar water to their forehead once daily for 21 days
• Either leave the micellar water on or rinse it off, depending on their group
• Undergo non-invasive measurements of TEWL, skin hydration, and erythema before and after the intervention

Enrollment: 30 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy adult volunteers aged 18 years and older. Willingness and ability to comply with study procedures. Signed informed consent indicating understanding of study participation, rights, and potential risks and benefits. No current skin diseases or conditions at the test site. Ability to attend all study visits and follow instructions

Exclusion criteria

• Participants with skin diseases, skin cancers, or sun damage at the test site will be excluded. Use of immunomodulators, corticosteroids, or antihistamines within 30 days prior to the study start is exclusionary. Application of emollient creams within 3 days before the trial is not permitted. Other exclusion criteria include protocol non-compliance, excessive exposure to natural or artificial ultraviolet radiation, pregnancy or lactation, history of vitiligo, melasma, or other hyperpigmentation or photosensitive disorders, immunosuppression, and allergy to any ingredient of the micellar solution used in the intervention. Before starting the study, participants will be asked if they have ever experienced adverse reactions to any components of the micellar solution.

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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30 participants in 2 patient groups

Micellar Water Application Without Rinsing

Experimental group

Description:

Participants apply micellar water to the forehead once daily and leave it on the skin without rinsing. Skin barrier function is assessed before and after 21 days of application.

Treatment:

Procedure: Micellar Water Application (No Rinse)

Micellar Water Application With Rinsing

Experimental group

Description:

Participants apply micellar water to the forehead once daily and rinse it off after application. Skin barrier function is assessed before and after 21 days of application.

Treatment:

Procedure: Micellar Water Application (With Rinse)