MICRO-RNAs OF NEUTROPHILS IN RENAL ANTINEUTROPHIL CYTOPLASMIS ANTIBODY (ANCA) -ASSOCIATED VASCULITIS (MINERVA)

Nantes University Hospital (NUH)

Status: Completed

Conditions: ANCA-associated Vasculitis

Treatments: Other: Non interventional study

Study type: Observational

Funder types: Other

Identifiers

NCT02954705

RC15_0454

Details and patient eligibility

About

Activation of neutrophils by ANCA ("Anti-Neutrophil Cytoplasm Antibodies") and subsequent microvascular endothelial cell damage is the main feature of ANCA-associated vasculitis (AAV), a severe autoimmune disease that often targets the kidney. There is no specific treatment for AAV to date and 25% of patients with renal damage evolve towards end-stage renal disease, requiring dialysis and kidney transplantation. In addition, there is no reliable biological marker of the disease activity available, which makes the diagnostic, follow-up and treatment of patients difficult. Therefore, the identification of new therapeutic targets and non-invasive biomarkers constitutes a major clinical challenge to improve AAV patients care and to ameliorate their renal outcome.

Enrollment: 63 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria for patients:

• Adult patients aged over 18 years
• Patients with Granulomatosis with polyangiitis or microscopic polyangiitis meeting the criteria of Chapel Hill.
• corticosteroid treatment <20 mg / day.
• Informed consent: oral for participation in research and writing for biological collection.

Inclusion Criteria for controls patients:

• healthy-topics matched for age, recruited from the Etablissement français du sang or in the Department of Internal Medicine of Nantes University Hospital

Non Inclusion Criteria:

• ANCA-associated vasculitis with Eosinophilic granulomatosis with polyangiitis (AAV-EGPA).
• Infectious or progressive tumor pathology.
• Pregnancy, lactation
• Treatment with cyclophosphamide in the 6 months prior to inclusion.
• Terminal chronic renal failure, presence of organ allograft.
• Thrust Patients receiving corticosteroids> 20 mg / d in the previous 4 weeks.
• Inability to give informed about information (subject in emergencies, understanding of the subject of difficulty, ...)
• Minor subject, under judicial protection, guardianship

Trial design

63 participants in 2 patient groups

Group AAV

Description:

Patients recruited from the Nantes University Hospital. 50 milliliter of blood and 10mL of urine are collected from these patients during levies in clinical visit.

Treatment:

Other: Non interventional study

Group control

Description:

People recruited from the "Etablissement français du sang" (French blood establishment ). 10 milliliter of blood are collected from these donors

Treatment:

Other: Non interventional study