Microarray Analysis of microRNA Expression Profiles in Cutaneous Squamous Cell Carcinoma

Ruhr University of Bochum

Status: Completed

Conditions: Cutaneous Squamous Cell Carcinoma

Study type: Observational

Funder types: Other

Identifiers

NCT01500954

microRNA7

Details and patient eligibility

About

MicroRNAs (miRNAs) are a novel class of short RNAs which have shown to be dysregulated in a variety of cancers. Data of miRNA expression in cutaneous squamous cell carcinoma (cSCC) is very limited and microarray based genome wide miRNA expression profiles of cSCC have not been investigated so far.

Full description

Patients with cutaneous SCC were enrolled in the present study. Tumor biopsies were taken from the center of the tumor. Adjacent healthy skin was biopsied as a control (intraindividual control). miRNA expression profiles of specimen were detected by microarray miRNA expression profiling. Microarray results were confirmed by TaqMan real-time quantitative polymerase chain reaction (RT-PCR).

Enrollment: 7 patients

Sex: All

Ages: 1+ year old

Volunteers: No Healthy Volunteers

Inclusion criteria

• cutaneous squamous cell carcinoma

Exclusion criteria

• other skin cancer than cutaneous squamous cell carcinoma

Trial design

7 participants in 2 patient groups

squamous cell carcinoma

non-lesional skin