Microaspiration in Pulmonary Fibrosis (ROMI)

University of California San Francisco (UCSF)

Status: Completed

Conditions: Idiopathic Pulmonary Fibrosis

Study type: Observational

Funder types: Other

Identifiers

NCT01150591

F32HL097383

Details and patient eligibility

About

Hypothesis 1: Microaspiration, as diagnosed by bronchoalveolar lavage (BAL) pepsin, is common in patients with IPF.

Hypothesis 2a: Baseline clinical variables and co-morbid conditions are risk factors for microaspiration in patients with IPF.

Hypothesis 2b: Baseline biological variables reflecting alveolar epithelial injury and inflammation are markers of microaspiration in IPF.

Hypothesis 3a: Microaspiration will lead to a more rapid rate of decline in pulmonary function.

Hypothesis 3b: Microaspiration will lead to higher rates of urgent medical care use (i.e. unscheduled clinic visit, emergency room visit, or hospitalization).

Enrollment: 20 patients

Sex: All

Ages: 18 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosis of IPF
• Ability ot provide informed consent

Exclusion criteria

• History of fundoplication or other gastroesophageal surgery
• Too ill to undergo bronchoscopy in the opinion of the investigator