Microbe-host Interaction Relationship in Patients With Stroke-relatedPneumonia

Guangzhou University of Traditional Chinese Medicine

Status

Not yet enrolling

Conditions

Stroke-related Pneumonia

Study type

Observational

Funder types

Other

Identifiers

NCT06161298

SAP20231201

Details and patient eligibility

About

This study intends to use a standardized cohort study to collect biological samples (including throat swabs, sputum and blood) from subjects eligible for inclusion, and use 16s DNA / metagenomic sequencing and metabolome technology to explore the microbial-host interaction relationship of SAP patients.

Full description

Stroke-related pneumonia (SAP) is the most common complication of acute cerebral hemorrhage, and it is one of the main causes of disease aggravation, prolonged hospitalization and costs, and even death. The traditional antibiotic model proved ineffective, and new prevention and treatment methods were urgently sought.This study intends to use a standardized and rigorous cohort study to collect biological samples (including throat swabs, sputum and blood) of eligible subjects, and to explore the microbial-host interaction relationship in patients with SAP, which may provide new targets and new ideas for the prevention and control of SAP.

Enrollment

240 estimated patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Age: 18 years old;
Stroke was confirmed by imaging;
Within 48 hours of onset, the onset time cannot be determined from the last normal observation;
Glasgow Coma Scale (GCS) 7-14;
SAP by clinical symptoms, laboratory examination or imaging confirmation, the modified CDC diagnostic criteria;
The patient (or his / her legal representative) signs a written informed consent form.

Exclusion criteria

Use of antibiotics within 4 weeks before stroke onset;
The presence of other conditions that may interfere with the follow-up and outcome assessment (such as known significant prestroke disability, mRS score of 3-5, end-stage malignancy, and liver and renal failure);
Pregnant or lactating women.