Microbial Diversity of Small Bowel Stoma Effluent and Colonic Faeces

Shanghai Jiao Tong University

Status

Unknown

Conditions

Intestinal Failure

Study type

Observational

Funder types

Other

Identifiers

NCT03590418

ShanghaiXinhua

Details and patient eligibility

About

Several studies suggested that dysbacteriosis usually happened in patients with intestinal failure (IF). However, differences of microbiota diversity in small intestine stoma effluents and colonic faeces were rarely studies. Thus this study is aimed to investigate the microbiota compositions and differences of output of small intestine stoma and colon in pediatric IF patients. Fecal samples from IF patients. Each patient received fistula closure in our centre and fecal samples from both small intestinal stoma and colon were collected. Fecal microbial compositions were determined by high-throughput sequencing.

Enrollment

60 estimated patients

Sex

All

Ages

1 month to 3 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Patients with intestinal failure. Patients showed good tolerance to parenteral and enteral nutrition administration. Proportion of enteral nutrition is more than 80%.

Stool output maintained at less than 50mL/kg/day. No complications occurred for at least 1 week.

Exclusion criteria

Patients depend mainly on parenteral nutrition. Symptoms like fever, abdominal distention and diarrhea. Complications like parenteral nutrition-associated liver disease, pneumonia and catheter related infection.