Microbiome Alterations in IL10RA-deficient Patients After HSCT

Fudan University

Status: Terminated

Conditions: Inflammatory Bowel Diseases; Microbiota

Treatments: Procedure: hematopoietic stem cell transplantation

Study type: Observational

Funder types: Other

Identifiers

NCT03752372

HSCT microbiomte

Details and patient eligibility

About

To elucidate the longitudinal development of intestinal microbiota in patients with IL10RA deficiency after hematopoietic stem cell transplantation (HSCT). The investigators planned to collect fecal samples from IL10RA-deficient patients who received HSCT. Samples were collected more than once every three days after engraftment in lamina flow ward and at least once a week before discharge. Microbial DNA was extracted from the fecal samples. And all analysis was based on the next generation sequencing data.

Full description

Hematopoietic stem cell transplantation is considered the only curative therapy for patients with interleukin-10 receptor-A(IL10RA) deficiency. The investigators aimed to collect the fecal samples of these patients throughout the conditioning, transplantation until discharge, providing a dense insight into the longitudinal development of intestinal microbiota.

Enrollment: 13 patients

Sex: All

Ages: 1 day to 6 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• IL10RA gene mutations;
• Eligible for hematopoietic stem cell transplantation.

Exclusion criteria

• Unwilling to participate.

Trial design

13 participants in 1 patient group

HSCT cohort

Description:

IL10RA-deficient patients who received hematopoietic stem cell transplantation

Treatment:

Procedure: hematopoietic stem cell transplantation