Microbiome and Colorectal Cancer Recurrence

Hospital del Mar

Status: Completed

Conditions: Colorectal Cancer Recurrent

Study type: Observational

Funder types: Other

Identifiers

NCT07057076

PI19/00643 (Other Grant/Funding Number)

2020/9513/I

SGR 00024 (Other Grant/Funding Number)

Details and patient eligibility

About

Anastomotic leak is associated with higher rates of tumor recurrence after colorectal cancer surgery. However, the mechanisms responsible remain unknown. The aim of this study is to identify associations between the peritoneal microbiome and recurrence in colorectal cancer patients with postoperative anastomotic leak. This is a single-center retrospective study of patients undergoing colorectal cancer surgery complicated with anastomotic leak between 2004 and 2012. Samples of peritoneal fluid were collected either through percutaneous drainage or reoperation, and microbiome was analyzed using whole genome shotgun. Oncological outcomes are registered. Associations between peritoneal microbiome and tumor recurrence are investigated.

Enrollment: 51 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Colorectal cancer patients operated on for cure and complicated with anastomotic leak.

Exclusion criteria

• Non-curative resection.
• Urgent surgery.

Trial design

51 participants in 1 patient group

Colorectal cancer patients

Description:

Colorectal cancer patients operated on for cure and complicated by anastomotic leak