Microbiome Composition Changes on 4 Week Gluten-free Diet Challenge

University Medical Center Groningen (UMCG)

Status: Completed

Conditions: Human Microbiome

Treatments: Other: Dietary intervention

Study type: Interventional

Funder types: Other

Identifiers

NCT02731976

M12.113965

Details and patient eligibility

About

Changes in the gut microbiomes of healthy volunteers who followed a gluten-free diet (GFD) for four weeks were studied. Per participant, nine stool samples were collected: one at baseline, four during the GFD period, and four when they returned to their habitual diet. Microbiome profiles were determined using 16S rRNA sequencing and the samples were next processed for taxonomic and imputed functional composition. Additionally, participants kept a 3-day food diary and six gut health-related biomarkers were measured.

Enrollment: 21 patients

Sex: All

Ages: 16+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy participants aged >=16

Exclusion criteria

• Known gastrointestinal disorder
• Known food intolerance

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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21 participants in 1 patient group

GFD

Experimental group

Description:

After instruction of a dietician, participants adhered to a gluten-free diet for 4 weeks.

Treatment:

Other: Dietary intervention