Microcirculation in Spontaneous Breathing Trial

National Taiwan University

Status: Completed

Conditions: Critically Ill

Treatments: Other: Microcirculation examination

Study type: Observational

Funder types: Other

Identifiers

NCT04711590

201909036RINB

Details and patient eligibility

About

Weaning ventilator support in critically ill patients is crucial. Both delayed extubation and unexpected early reintubation are harmful to the patients. Weaning parameters and spontaneous breathing trial are used to investigate the indication and predict the successful extubation. Hemodynamic stability and physical reserve are important indicators as well. Microcirculation parameters are known to be more sensitive to the change of hemodynamic status than macrocirculation parameters. We hypothesize that the change of sublingual microcirculation before and after spontaneous breathing trial is different between the the patients with successful extubation and the patients with failed extubation. Thus, this study measures sublingual microcirculation in patients receiving spontaneous breathing trial and record the extubation status (successful or failed). The microcirculation parameters before and after spontaneous breathing trial are compared between the the patients with successful extubation and the patients with failed extubation.

Enrollment: 59 patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• critically ill patients received ventilator longer than 12 hours
• ready for spontaneous breathing trial
• GCS coma score equal or higher than 8

Exclusion criteria

• aged less than 20 years
• patient with tracheostomy
• patient and patients' relatives are non-native speakers

Trial design

59 participants in 2 patient groups

Successful extubation

Description:

The patients pass the spontaneous breathing trial and are successful extubated without reintubation within 72 hours. .

Treatment:

Other: Microcirculation examination

Failed extubation

Description:

The patients pass the spontaneous breathing trial and are successful extubated with reintubation within 72 hours. .

Treatment:

Other: Microcirculation examination