Microcirculatory Changes During Magnesium Sulphate Infusion in Sepsis

Medical Centre Leeuwarden

Status: Completed

Conditions: Severe Sepsis; Septic Shock

Treatments: Drug: Magnesium Sulfate

Study type: Observational

Funder types: Other

Identifiers

NCT01332734

2010-03.03 nr BE-2-6

Details and patient eligibility

About

During infections (sepsis) bloodflow in small vessels (microcirculation) becomes disturbed. Restoration of bloodpressure and cardiac performance may not be sufficient to correct these alterations. Magnesium is a potent vasodilator which may be used to open up the small vessels, in order to reduce organ failure.

Full description

In a single-center open label study we evaluated the effects of magnesium sulphate (MgS) infusion on the sublingual microcirculation perfusion in fluid resuscitated patients with severe sepsis and septic shock within the first 48 hours after ICU admission. Directly prior to and after 1 hour of magnesium sulphate (MgS) infusion (2 gram) systemic hemodynamic variables, sublingual SDF images and standard laboratory tests, were obtained.

Enrollment: 14 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• severe sepsis and septic shock

Exclusion criteria

• pregnancy
• oral bleeding
• age < 18 years
• liver cirrhosis
• acute arrhythmias
• advanced malignancy or a mean arterial pressure (MAP) < 65 mmHg refractory to vasopressors

Trial design

14 participants in 1 patient group

severe sepsis and septic shock

Treatment:

Drug: Magnesium Sulfate